Catalytic subunit in active conformation. |
Protein kinase A (PKA) refers to a family of enzymes whose activity is dependent on the level of cyclic AMP (cAMP) in the cell. [low cAMP levels result in an inactive PKA] [high cAMP levels result in an active PKA] PKA is also known as cAMP-dependent protein kinase EC (2.7.11.11) is a quarternary holoenzyme made of 2 Regulatory & 2 Catalytic subunits. Protein kinase A has several functions in the cell, including regulation of glycogen, sugar, and lipid metabolism via transfer of terminal P on ATP to SER on proteins... |
animation of action* protein --PKA + ATP --> protein-Ser-P + ADP | |
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