Cell and Molecular Biology is a domain where the disciplines of Biology, Computer Science, Logic, Quantum Physics, and Nanotechnology intersect and at its heart may be the concept of Information Processing. |
What may distinguish Life
from Non-Life is Information Processing... "a living cell is a magic puzzle box full of elaborate and changing molecules" paraphrased from Max Delbruck [1949) - biophysicist & Nobel winner 1969 |
Atoms and molecules are
the hardware of Life.
Where is the software of LIfe?
Living organisms through billions of years of evolution have achieved goals (survival and reproduction), whereas atoms and molecules blindly follow the Laws of Physics and Chemistry. Where is the missing link? |
Possibly... Information Theory, as an abstract concept like energy and entropy. Information is familiar and pragmatic, yet it is also abstract and mathematical. Information Theory involves the mathematical treatment of the concepts, parameters and rules governing the transmission of "messages and knowledge", emergent characteristics and properties that a system gains as it becomes part of a more complex system. |
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Epigenetics and Information Processing in Cells: Epigenetics: epigenetics is
the study of heritable phenotype
changes that do not involve alterations in the
DNA sequence and are passed from generation to
generation. Epigentics suggests there is more than just
DNA in information flow.
Experiments with Planaria:
using drugs to disrupt electrical
fields in planaria, when cut in half instead of
getting a tail --> new head and a head --> a new
tail, one could get tail -->
tail and head -->
head, and even 2 tailed and 2 headed planaria.
And if the 2nd
head is removed and the planaria cut in half, these
planaria would make another
2-headed worm. |
Even with identical DNA genomes, dramatically
different phenotypes occur, possibly by the
passage across generations of epigenetic modifications to
the informational content of the organisms. |
Where is the morphological information stored in these worms and how is it passed to subsequent generations including the information to grow to just the correct size new tail or new head? |
Another example:
in some deer species that
grow antlers each season, one can notch
the antler before next years new growth. After
last years antlers fall off and the new antlers appear,
they will have an eptopic branch (tine) at the notches
location.
Where is the new notches information
stored in these deer. Epigenetic markers are
methylations, histone modifications to DNA nucleosomes,
and other patterns that influence gene expressions are
passed, as information content,
to daughter cells in a non-genetic fashion.
Understanding where
and how non-genetic information processing is accomplished
by cells is a major question for biology and the study of
life. |
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