E1: pyruvate decarboxylase - thiamine pyrophosphate
         TPP removes COOH from pyruvate leaving
         2 carbon fragment that binds the acyl
         fragment to the TPP.

 E2: lipomide reductase transacetylase - lipoate
         2 carbon acyl group is transferred  to one
         lipoamide arm, and then to the other,
         to position it for CoASH transfer.

 E3: dihydrolipoyl dehydrogenase- CoASH, FAD, NAD⁺
         acyl group is transferred to CoASH;
         the reduced lipoamides transfers 
         2H's to E-FAD -->  E-FADH₂,  and then
         E-FADH₂ passes H to NAD⁺ --> NADH
                O                           O 
                ||                            ||
           CH₃-C-COOH   ----->  CH₃-C-SCoA 
                         NAD -----------> NADH     
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