Collagen Fibers & Wounds |
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A wound is a break in the tissues of the body. Some injuries, like cuts and scrapes, are called open wounds; others, like deep bruises, are called closed wounds. They are usually caused by external forces such as motor vehicle accidents, falls, burns, and the mishandling of sharp objects, tools, machinery, and weapons. |
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Laser |
Up to 5,000,000 wounds, many chronic, occur every year in the U.S. When skin is injured, the natural
"weave-like" structure of the collagen fibers is destroyed. Collagen
is the major structural protein of skin and is responsible for its tensile
strength, elasticity, and pliability. It is synthesized in the dermis by
FIBROBLASTS. |
Some current research solutions to helping wound repairing: [skin cell culture] |
1. cultured human dermal tissue - Artificial Skin...[Apligraft / Dermagraft] a bioengineered product that contains cultured (lab-grown) human dermal material (including the foreskin of circumsized infants), proteins, and growth factors. Applied to the wound, this material proliferates, generating new human dermal tissue. Dermagraft foreskin can be grown on layered matrix substrates (polymer fibers) making skin grafts that secrete growth factors. |
2.
ELECTROSOLS - Oxford Biotech Company |
3. CHITOSAN - a chitin based material derived from crab shells, may help provides a scaffold for skin cell growth. Applied in a 3 layer dressing: a) Chitosan on teflon sheets, b) a starch-based polymer (which helps transport away pus and edema), and cotton gause. The body absorbs the Chitosan leaving new skin in its place. |
4.
OaSIS - Small Intestine Sub-mucosa |
© cmallery - july 2000
last update -
March 30, 2007