discovered in the former Zaire and Sudan in 1976 with a fatality rate of 90%
single stranded RNA virus of Filovirida family (pics*)
19K nucleotides --> 8 protein including surface glycoprotein (used for vaccines?)
Ebola is immunosuppressive
infects monocytes first, then spreads to phagocytes, endothelial cells, & liver cells
causing release multiple cytokines (fever & inflammation) and apoptosis, loss in
vascular integrity --> intravasculature coagulation --> fibrin clots --> hemorrhage
easily killed via paraformaldehyde
vaccines & passive immunity trials are in early days of testing (summer 2014)
* may have been weaponized by Russians (Biohazard by Ken Alibeck)
Ebola virus is so deadly due to its ease of entry into host cells.
the virion coat contains a 'spike' protein [glycoprotein] whose crystallized structure was recently
determined by X-ray crystallography at Scripps in LaJolla by immunologist Erica Saphire and her research
group (Nature 454: 177-182, 2008). the GP's attach easily to host and drive virion into a host cell.
the virion's receptor binding site is a mucin-like domain at the center-base of a chalice shape made by three GP1 proteins and protected by a canopy of the GP1's. The chalice is cradled by GP2 subunits. The canopy is likely shed as the virion approaches a host allowing binding of the mucin domain to the host.
