Y
Chromosome
XY
*
- is much smaller than its homolog, the X chromosome
- 200 to 300 million years ago Y
held genes equal to the X
chromosome
- today X &
Y share just 78 genes. The Y chromosome holds a core of 12 genes
involved in vital cell
functions in the heart, blood, and lungs.
- also involved
in male fertility (codes for testes proteins - many are repeat
amplified)
- holds some "housekeeping genes" (†) & genes with homology to the "X" (‡)
(fig)
- holds lots of
"junk" DNA
& STR's
(Short Tandem Repeats)
- holds a gene
- SRY (sex
determining region) encodes a protein that triggers
formation of testes by activating genes on several of the autosomes.
X
& Y evolved from a
matching pair of autosomes some
240 to 320 millions years ago
tips of X
& Y can engage in recombination, but rest of Y can not
the degeneration of Y chromosome occurred
after evolution of SRY gene,
because
of a loss of ability to recombine during meiosis...
without recombination genes on
Y mutated, stopped working, &
degenerated (fig)
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