Table of half-life of some mRNAs |
mRNA species |
Half-life (Hours) |
Glyeraldehyde 3-P dehydrogenase | 75-130 |
Fatty acid synthetase | 48-96 |
β-actin (nonmuscle) | 60 |
Cytochrome P450 | 36 |
Pyruvate kinase | 30 |
Glu-6-Phosphate dehydrogenase | 15 |
Insulin receptor | 9 |
Tubulin | 4 -12 |
Thymidine kinase | 2.6 |
Glucocorticord receptor | 2.3 |
Tyrosine aminotransferase | 2.0 |
Heat Shock Proteins (70hsp) | 2.0 |
Ornithine decarboxylase | 0.5 |
most bacterial mRNA's | < 3.0 minutes |
Longevity of some Proteins
Protein Species |
Longevity |
crystallin lens protein | life of organism (90 yr+) |
hemoglobin | life of RBC (3 month humans) |
Steroid hormone receptor | short lived (hours) |
Casein (milk protein) | short lived (hours) |
HSP 70 proteins | short lived (hours) |
cyclins (cell division) | short lived (hours) |
transcription factors | short lived (hours) |
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