Table of half-life of some mRNAs

mRNA species

Half-life (Hours)

 Glyeraldehyde 3-P dehydrogenase 75-130
 Fatty acid synthetase 48-96
 β-actin (nonmuscle) 60
 Cytochrome P450 36
 Pyruvate kinase  30
 Glu-6-Phosphate dehydrogenase 15
 Insulin receptor 9
 Tubulin 4 -12
 Thymidine kinase 2.6
 Glucocorticord receptor 2.3
 Tyrosine aminotransferase 2.0
 Heat Shock Proteins (70hsp) 2.0
 Ornithine decarboxylase 0.5
 most bacterial mRNA's < 3.0 minutes






Longevity of some Proteins

 Protein Species


 crystallin lens protein life of organism (90 yr+)
 hemoglobin life of RBC  (3 month humans)
 Steroid hormone receptor short lived (hours)
 Casein (milk protein) short lived (hours)
 HSP 70 proteins short lived (hours)
 cyclins (cell division) short lived (hours)
 transcription factors short lived (hours)